Wednesday, June 5, 2019

Early and LATE Dementia

From the day Jim was diagnosed with an Alzheimer’s type of dementia, I researched the disease through all sources possible. I used the Internet, books, pamphlets, watched TV specials, and talked to some of the top researchers in the country.

My conclusion was that early onset dementia and dementia in older people seemed to be two different diseases. It seemed obvious to me that early onset progressed much faster. That didn’t seem logical since younger people generally started out with healthier bodies. Yet, I found that the median life expectancy of younger-onset Alzheimer’s was six to eight years. For those diagnosed with Alzheimer’s later in life, the average life expectancy was ten years, but could be as long as twenty years or more.

Now, researchers have discovered that some seniors who had been diagnosed with Alzheimer’s actually had a type of dementia identified as LATE (Limbic-predominant Age-related TDP-43 Encephalopathy).

Although LATE mimics Alzheimer’s disease, the proteins beta-amyloid plaques and tau tangles that are the hallmark signs of Alzheimer’s do not cause the dementia. LATE is caused by deposits of the protein TDP-43 (transactive response DNA binding protein of 43 kDa) in the brain.

The report identifying LATE was published in the April 30, 2019, issue of the journal Brain. This is a major breakthrough in how researchers will look at dementia in older adults. LATE is believed to affect 25% of seniors with dementia who are eighty-five years or older. 

At the Alzheimer’s Advocacy Forum in Washington, D.C., advocates often receive reports from Richard Hodes, M.D. director of the National Institute on Aging (NIA), part of the National Institutes of Health (NIH).  This latest development in the study of dementia can be seen as an opportunity. Dr. Hodes said, “The guidance provided in this report, including the definition of LATE, is a crucial step toward increasing awareness and advancing research for both this disease and Alzheimer’s as well.”

Abnormal TDP-3 had been previously identified in ALS (amyotrophic lateral sclerosis) also known as Lou Gehrig’s disease. TDP-3 has been found in FTLD (frontotemporal lobar degeneration). FTLD is a group of disorders that affects the frontal and/or temporal areas of the brain. FTD (frontotemporal degeneration) is a rare disease more commonly found in those younger than sixty years of age.

The progression of LATE is slower than Alzheimer’s disease. When LATE and Alzheimer’s disease are both present, the disease progresses more rapidly than either disease does alone.
The information from this study came from brain autopsy reports. We had an autopsy on Jim’s brain for the simple reason that I wanted to know what disease he had and whether it was hereditary. Of several terms used in his autopsy, I recognized a few: neurodegenerative disorder, incidental Lewy body, frontotemporal atrophy, swollen neurons, and tau positive glial inclusions. The cover letter said that Jim showed no signs of Alzheimer’s. He had corticobasal degeneration, a rare (non-hereditary) disease, and one I had never heard of.

Treatments targeting beta amyloid plaques would not be effective in a disease that does not have the plaques. Rare diseases do not have the funding of diseases that are more common. Funding Alzheimer’s research is our greatest hope of finding effective treatment for other types of dementia.


Copyright © June 2019 by L.S. Fisher


Unknown said...

I have been suffering from amyotrophic laterals sclerosis (ALS) disease for the last three years and had constant pain, especially in my knees.I was tripping and unable to get upstairs due to (ALS), My doctor put me on riluzole, letting me know there was no cure but the medication might provide me a few more months of delayed symptoms.The Rilutek (riluzole) did very little to help me. The medical team did even less. My decline was rapid and devastating. The psychological support from the medical centre was non-existent and if it were not for the sensitive care and attention of my primary physician, I would have died. There has been little if any progress in finding a cure. With the help of Organic Clinic natural herbs I have been able to reverse my symptoms using herbs, which i feel has made the most difference. The ALS natural formula immensely helped my condition, it reversed my ALS. my slurred speech. And then the inability to eat without getting choked, and the Pains. gradually disappeared. Visit Organic Herbal Clinic via their official web-site www. organicherbalclinic. com. I’m now playing golf again. and i turned 68 today. DON’T GIVE UP HOPE!!

Ana Verma said...

I am looking for such an informative post for a long time. Thank you for this post.Thank you for sharing your expertise. This post is very helpful. It's informative too! Hammond Institute

diploma of community service
certificate 4 in disability
government funded aged care courses online
government funded aged care courses online
certificate iv in education support
diploma of community services dandenong
certificate 4 in education support
diploma of community services government funded
diploma of community service
Advanced diploma of community sector management